Neonatal Seizure Models to Study Epileptogenesis
نویسندگان
چکیده
منابع مشابه
Late-onset epileptogenesis and seizure genesis: lessons from models of cerebral ischemia.
Patients surviving ischemic stroke often express delayed epileptic syndromes. Late poststroke seizures occur after a latency period lasting from several months to years after the insult. These seizures might result from ischemia-induced neuronal death and associated morphological and physiological changes that are only partly elucidated. This review summarizes the long-term morphofunctional alt...
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Neonatal seizures continue to be a diagnostic and therapeutic challenge to the clinicians. Seizures can permanently disrupt neuronal development, induce synaptic reorganisation, reduce neurogenesis, alter plasticity and prime the brain to increased seizures later in life1. The prevalence of seizures is 2-3 /1000 live births in term and 10-15 /1000 in preterm deliveries2. Diagnostic and therapeu...
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Epilepsy, one of the most common chronic neurological disorders, is characterized by recurrent spontaneous seizures. Seizures result from many causes including genetic or developmental defects, traumatic brain injury, substance abuse, infection, fever, metabolic disturbances, withdrawal symptoms and space-occupying lesions in the brain. Memamphetarnine (METH), a schedule II drug, leads to seizu...
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Epilepsy is a chronic neurological condition, following some trigger, transforming a normal brain to one that produces recurrent unprovoked seizures. In the search for the mechanisms that best explain the epileptogenic process, there is a growing body of evidence suggesting that the epilepsies are network level disorders. In this review, we briefly describe the concept of neuronal networks and ...
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INTRODUCTION Screening of newborns with seizure, who have curable pathologic brain findings, might be able to improve their final outcome by accelerating treatment intervention. The present study aimed to evaluate the brain ultrasonography findings of newborns hospitalized with complaint of seizure. METHODS The present cross-sectional study designed to evaluate brain ultrasonography findings ...
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2018
ISSN: 1663-9812
DOI: 10.3389/fphar.2018.00385